Emeritus Professor Dr Werner Muller
Emeritus Professor Dr Werner Muller
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis.
LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1.
T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation.
Common cytokine receptor gamma chain (gammac)-deficient B cells persist in T cell-deficient gammac-mice and respond to a T-independent antigen.
Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally.
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress.
Rearrangement and expression of immunoglobulin light chain genes can precede heavy chain expression during normal B cell development in mice.
Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects.
L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes.
c-fos expression interferes with thymus development in transgenic mice.
Generation of Cre recombinase-specific monoclonal antibodies, able to characterize the pattern of Cre expression in cre-transgenic mouse strains.
Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.
Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice.
Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination.
Conditional gene targeting.
Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants.
Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue.
Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development.
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance.
A role for CD5 in TCR-mediated signal transduction and thymocyte selection.
Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.
Mouse anti-mouse IgD monoclonal antibodies generated in IgD-deficient mice.
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.
Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies.
Resistance to murine acquired immunodeficiency syndrome (MAIDS)
Analysis of the B-cell progenitor compartment at the level of single cells.
Lymphocyte populations and immune responses in CD5-deficient mice.
Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.
Early B-cell development in the mouse: insights from mutations introduced by gene targeting.
Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4.
Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development.
Interleukin-10-deficient mice develop chronic enterocolitis.
T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells.
A critical role of lambda 5 protein in B cell development.
Generation of long-lived B cells in germ-free mice.
Most peripheral B cells in mice are ligand selected.
Major histocompatibility complex class II hyperexpression on B cells in interleukin 4-transgenic mice does not lead to B cell proliferation and hypergammaglobulinemia.
Generation and analysis of interleukin-4 deficient mice.
CD5 B cells in the mouse.
Membrane-bound IgM obstructs B cell development in transgenic mice.
Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts.
A new V gene expressed in lambda-2 light chains of the mouse.
Lymphokines regulate immunoglobulin isotype expression in an antigen- specific immune response.
Signal requirements for growth and differentiation of activated murine B lymphocytes.
Heterogeneous and monoclonal helper T cells induce similar anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response. I. Isotype distribution.