A Brunn

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• Neuronal gp130 expression is crucial to prevent neuronal loss, hyperinflammation, and lethal course of murine Toxoplasma encephalitis.
• Gp130-dependent astrocytic survival is critical for the control of autoimmune central nervous system inflammation.
• Astrocyte gp130 expression is critical for the control of Toxoplasma encephalitis.
• Molecular mimicry between neurons and an intracerebral pathogen induces a CD8 T cell-mediated autoimmune disease.